Abstract #4410

High-resolution 3D T1 and T2 Mapping in the Brain Using Compressed Sensing and Dictionary Fitting

Emilie Mussard^1,2,3, Tom Hilbert^1,2,3, Christoph Forman⁴, Reto Meuli², Jean-Philippe Thiran³, and Tobias Kober^1,2,3

¹Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, ²Department of Radiology, University Hospital (CHUV), Lausanne, Switzerland, ³LTS5, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, ⁴Magnetic Resonance, Siemens Healthcare GmbH, Erlangen, Germany

Quantitative magnetic resonance imaging (qMRI) aims at directly measuring physical tissue properties to be more independent from technical influences. However, parameter mapping is often long and 2D-based. In this work, we propose a protocol for 3D brain T1 and T2 mapping accelerated by compressed sensing. To improve T2 accuracy, we also implemented a T1-informed T2 dictionary fitting technique. Preliminary results showed the ability of the protocol to provide T1 and T2 maps at a 1x1x1.2mm³ resolution in 14:05min as well as the accuracy of the mapping. Establishing a fast 3D protocol will enable generating high-resolution atlases as a next step.

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