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Abstract #4411

Effects of acquisition and compressed sensing reconstruction parameters on 3D-QALAS multi-parameter quantitation and synthetic imaging of the brain

Ken-Pin Hwang1, Marcel Warntjes2, Naoyuki Takei3, Suchandrima Banerjee3, Drew Mitchell1, R. Jason Stafford1, Linda Chi4, and David Fuentes1

1Department of Imaging Physics, The University of Texas M.D. Anderson Cancer Center, Houston, TX, United States, 2SyntheticMR, Linkoping, Sweden, 3GE Healthcare, Waukesha, WI, United States, 4Department of Radiology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, United States

3D QALAS is a promising new technique that simultaneously maps T1, T2, and PD in a single 3D acquisition. We investigate the robustness of this technique to several acquisition and compressed sensing reconstruction parameters in phantom and brain images. Parameter maps were shown to be robust to B1 through the center portion of the slab, while compressed sensing did not demonstrate any effects on parameters in phantom or cause additional artifacts on parameter maps in human brain. 3D QALAS thus presents an attractive quantification method for therapy planning and tissue volume measurement applications.

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