Abstract #4453

Repeatability of T2 Relaxation Measurements over a Four-Year Period

Xing Wang^1,2, Cheryl R McCreary^2,3, Marina Salluzzi^3,4, and Richard Frayne^1,2

¹Medical Sciences, Radiology and Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada, ²Seaman Family MR Centre, Foothills Medical Centre, Alberta Health Services, Calgary, AB, Canada, ³Radiology and Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada, ⁴Calgary Image Processing and Analysis Centre (CIPAC), Seaman Family MR Centre, Calgary, AB, Canada

The reliability of a T2 relaxation quantification technique was assessed by repeatedly scanning four subjects (total of 12 scans at 4 time points over 4 years). Both total, biological and scanner variability were assessed across the whole brain and in the frontal, occipital, parietal temporal lobes. Total variability (coefficient-of-variation CoV < 10.3%) was dominated by biological variation (CoV < 10.3%). Scanner variability was low (CoV < 1.6%) despite scanner software and hardware upgrades during this interval. These results suggest that quantitative T2 estimates are reproducible over 4 years and robust to scanner upgrades.

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