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Abstract #4457

Exploring the sensitivity of Magnetic Resonance Fingerprinting to k-space trajectory uncertainties

Alessandro Palombit1,2, Alessandra Bertoldo1,2, Zidan Yu3,4,5, Riccardo Lattanzi3,4,5, and Martijn Anton Cloos3,4,5

1Information Engineering, University of Padova, Padova, Italy, 2Padova Neuroscience Center, Padova, Italy, 3Center for Advanced Imaging Innovation and Research (CAI2R), New York, NY, United States, 4Bernard and Irene Schwartz Center for Biomedical Imaging, New York, NY, United States, 5New York University School of Medicine, The Sackler Institute of Graduate Biomedical Sciences, New York, NY, United States

In this work, we experimentally explore the sensitivity of Magnetic Resonance Fingerprinting (MRF) to k-space trajectory uncertainties typically encountered in non-cartesian imaging. We demonstrate that T1 and T2* quantification can be affected by minor gradient delays observed in stack-of-stars 3D MRF implementations, particularly resulting in severely disrupted T2* measures. As a first approximation, we modeled these imperfections as constant readout sampling shifts of a few integer k-space steps along every trajectory direction. We show that by simply shifting back the nominal sampling locations before the reconstruction can restore reliable MRF parametric estimates.

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