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Abstract #4464

Assessment and optimisation of bias field correction using N4ITK for PD mapping

Sara Lorio1 and David W Carmichael2

1UCL, London, United Kingdom, 2KCL, London, United Kingdom

Proton density (PD) maps measure the amount of free water molecules in the tissue and can be used in a range of neurological disorders. We previously developed a new approach for PD mapping based on a multi-contrast acquisition protocol, and a data-driven estimation method for inhomogeneity correction and map scaling. Here we evaluate the robustness of the inhomogeneity correction method and its effect on the PD value estimation using data acquired with different receiver coils. This allowed us to assess the impact of the spatial variability of the receiver coil profile on the PD map.

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