Many coil combination methods have been developed, including methods that require pre-calibrated coil sensitivity maps, as well as methods that do not require additional sensitivity maps. Several of these methods have been adapted to CSE-MRI, where accurate signal combination is particularly critical as it needs to preserve consistent phase and magnitude information across echoes; however, their relative performance remains unknown. Therefore, the purpose of this work is to compare theoretically, in simulation, and experimentally the bias and noise performance of quantitative parameter maps resulting from five commonly used coil multi-echo coil combination techniques.
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