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Abstract #4468

Repeatability and Reproducibility of brain volume measurements with SPM and Freesurfer  and their impact on subtle between-group differences

Letizia Palumbo1, Paolo Bosco1, Elisa Ferrari2, Piernicola Oliva3, Giovanna Spera1, and Alessandra Retico1

1National Institute for Nuclear Physics (INFN), Pisa, Italy, 2Scuola Normale Superiore, Pisa, Italy, 3University of Sassary and INFN Cagliari Division, Sassari, Italy

The main aim of the study is to investigate whether the adoption of a processing method has a relevant influence on the results of a neuroimaging research. We evaluated the intra-method repeatability and the inter-method reproducibility of two widely-used automatic segmentation methods for brain MRI: FreeSurfer (FS) and Statistical Parametric Mapping (SPM) software packages. We segmented the gray matter, the white matter and the subcortical structures in test-retest MRI data of healthy volunteers from two publicly available datasets. High intra-method repeatability was found for both SPM and FS, but SPM was more consistent than FS in measuring ROIs volumes.

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