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Abstract #4469

The Effect of Membrane Lipids on qMT Exchange Constants

Oshrat Shtangel1 and Aviv Mezer1

1The Hebrew University, Jerusalem, Israel

Quantitative Magnetization Transfer(qMT) is a proposed method for deeper characterization of brain tissue. Yet, a connection between qMT parameters and the components of cellular tissue is required. Myelin is composed of various types of lipids, which their amount and composition are changed between brain areas, disease states and across the lifespan. In this work, we formulated liposomes to model the environment of abounded lipids in the human brain and systematically estimated their effect on qMT parameters. We found qMT technique useful to identify differences between lipids. This result can pave the way to future research the molecular environments of human tissue in-vivo.

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