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Abstract #4471

Influence of image processing on the robustness of radiomic features derived from magnetic resonance imaging - a phantom study

Barbara D. Wichtmann1, Ulrike I. Attenberger1, Felix N. Harder1, Stefan O. Schönberg1, David Maintz2, Kilian Weiss3, Daniel Pinto dos Santos2, and Bettina Baeßler1,2

1Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, 2Department of Radiology, University Hospital of Cologne, Cologne, Germany, 3Philips Healthcare Germany, Hamburg, Germany

The emerging field of radiomics aims at analyzing quantitative features derived from medical images to characterize tissue and support clinical decision-making. However, an extensive knowledge about the robustness and reproducibility of radiomic features has to precede translation into routine clinical practice. Very little is known regarding the robustness of radiomic features derived from magnetic resonance imaging. We want to assess the influence of image processing parameters on the robustness of radiomic features. Our results showed that variation of image processing parameters has considerable impact on the robustness as well as on absolute values of radiomic features extracted from MRI data.

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