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Abstract #4472

Repeatability of radiomic features for prostate cancer diffusion weighted imaging obtained using b-values up to 2000 s/mm2

Harri Merisaari1, Rakesh Shiradkar2, Jussi Toivonen1, Amogh Hiremath2, Mohammadhadi Khorrami2, Ileana Montoya Perez1, Tapio Pahikkala1, Pekka Taimen1, Janne Verho1, Peter J Boström3, Hannu Aronen1, Anant Madabhushi2, and Ivan Jambor1,4

1University of Turku, Turku, Finland, 2Case Western Reserve University, Cleveland, OH, United States, 3Turku University Hospital, Turku, Finland, 4Icahn School of Medicine at Mount Sinai, New York, NY, United States

We evaluated repeatability and diagnostic performance of commonly used radiomic features for prostate cancer (PCa) DWI obtained using b values up to 2000 s/mm2. Forty-eight men with diagnosed PCa under two repeated 3T MRI examinations performed on the same day. Whole mounts prostatectomy sections were manually matched with in-vivo MRI data. Fourteen of the evaluated 575 features demonstrated high repeatability with ICC(3,1)>0.9 and AUC(Gleason score 3+3 vs >3+3 PCa)>0.6. Many of the conventional radiomics feature demonstrate high AUC but low repeatability (low ICC(3,1) values)stressing the fact that high classification potential using single acquisition does not necessarily mean good overall performance.

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