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Abstract #4484

Groupwise Non Rigid Registration For Temporal Myocardial Arterial Spin Labeling Images

Veronica Aramendía-Vidaurreta1, Pedro Macías-Gordaliza2,3, Marta Vidorreta4, Rebeca Echeverria-Chasco1, Gorka Bastarrika1, Arrate Muñoz-Barrutia2,3, and María Fernández-Seara1

1Radiology, Clínica Universidad de Navarra, Pamplona, Spain, 2Universidad Carlos III de Madrid, Madrid, Spain, 3Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain, 4Siemens Healthineers, Madrid, Spain

Arterial Spin Labeling (ASL) enables quantitative measurement of myocardial blood flow (MBF) by averaging over multiple ASL pairs providing a voxelwise map in units of milliliters of blood per gram of tissue per minute (ml/g/min). However, its estimation accuracy in free breathing acquisitions depends critically on the quality of the image registration algorithm. In this work, a groupwise non-rigid registration method with a similarity measure based on Principal Component Analysis (PCA) was applied to ASL images of the heart acquired during free breathing. The method was compared against a pair-wise registration algorithm provided by the advanced normalization tools software (ANTs). Results demonstrate the feasibility of using PCA-groupwise for temporal ASL image registration.

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