Abstract #4537

Practical Considerations for Mapping R1 in the Cerebral Cortex Across Sites

Laagi Yoganathan¹, Kim Desmond¹, Manpreet Sehmbi², Benicio N Frey², and Nicholas Bock¹

¹Psychology, Neuroscience & Behaviour, McMaster University, Hamilton, ON, Canada, ²Psychiatry & Behavioural Neuroscience, McMaster University, Hamilton, ON, Canada

We map R₁ in the cortex across two sites, using IR-GRE and GRE images to calculate R₁ values based on the ratio of the images (IR-GRE/GRE)) using signal equations. We collect B₁+ maps to analytically correct R₁ inhomogeneities that might cause site-dependent variation. We tested our R₁ mapping method with two different input ratio images: one formed using an IR-GRE sequence with typical neuroanatomical contrast, and one using an IR-GRE sequence optimized to produce strong intracortical contrast. We found the ratio image with the higher intracortical contrast produced more consistent R₁ maps across sites, which were less sensitive to B₁+.

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