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Abstract #4537

Practical Considerations for Mapping R1 in the Cerebral Cortex Across Sites

Laagi Yoganathan1, Kim Desmond1, Manpreet Sehmbi2, Benicio N Frey2, and Nicholas Bock1

1Psychology, Neuroscience & Behaviour, McMaster University, Hamilton, ON, Canada, 2Psychiatry & Behavioural Neuroscience, McMaster University, Hamilton, ON, Canada

We map R1 in the cortex across two sites, using IR-GRE and GRE images to calculate R1 values based on the ratio of the images (IR-GRE/GRE)) using signal equations. We collect B1+ maps to analytically correct R1 inhomogeneities that might cause site-dependent variation. We tested our R1 mapping method with two different input ratio images: one formed using an IR-GRE sequence with typical neuroanatomical contrast, and one using an IR-GRE sequence optimized to produce strong intracortical contrast. We found the ratio image with the higher intracortical contrast produced more consistent R1 maps across sites, which were less sensitive to B1+.

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