Quantitative DCE-MRI requires fast pre-contrast T1 mapping (scan time <3 min) with matching resolution and coverage. Recent advances in imaging have substantially improved resolution and coverage of DCE-MRI but without matched improvements in the pre-contrast T1 data. Here, we demonstrate a sparse T1 mapping method and characterize a tradeoff between data acquisition and T1 statistics, using a variable flip angle (VFA) approach and sparse Cartesian spiral sampling pattern, with image domain wavelet sparsity constraint. This method provides the necessary high-resolution whole-brain T1/M0 maps for DCE-MRI tracer kinetic analysis.
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