Abstract #4669

High-Resolution Simultaneous Mapping of Brain Function and Metabolism

Rong Guo^1,2, Yibo Zhao^1,2, Yudu Li^1,2, Yao Li³, and Zhi-Pei Liang^1,2

¹Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ²Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ³Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China

We present a new method for simultaneous mapping of brain function and metabolism. This method provides an unprecedented capability to simultaneously obtain high-resolution metabolic maps (2.4×2.4×3.0 mm³) and brain functional maps (3.0×3.0×2.6 mm³) of the whole brain coverage (230×230×120 mm³) in 8 minutes. The proposed method extends the subspace-based imaging framework of the SPICE technique with a new data acquisition scheme and exploits the complementary information between MRSI and fMRI signals for high-quality image reconstruction. Brain imaging experiments have been carried out, demonstrating the impressive capability of our method. With further improvement, the method can provide an unprecedented tool for mapping brain function and metabolism simultaneously.

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