To assess the extent and dynamics of short-term apparent change (SAC) of GM in motor training we investigated how the VBM results are affected by the different levels of acceleration of the MP-RAGE sequence using the wave-CAIPI technique which provides highly accelerated MPRAGE imaging and retain high image quality. The optimized wave-CAIPI MPRAGE imaging protocol overcomes the g-factor noise amplification penalty and allows for over an order of magnitude acceleration of MPRAGE imaging in VBM studies. The standard and wave-CAIPI MPRAGE sequences have different sensitivity in detecting SAC of GM likely due to their differences in noise and contrast characteristics.
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