Abstract #4673

Simultaneous B1- and Fat-Corrected T1 Mapping Using Chemical-Shift Encoded MRI

Nathan Tibbitts Roberts^1,2, Diego Hernando^1,3, Timothy J Colgan¹, Xiaoke Wang^1,4, and Scott B Reeder^1,3,4,5,6

¹Radiology, University of Wisconsin - Madison, Madison, WI, United States, ²Electrical and Computer Engineering, University of Wisconsin - Madison, Madison, WI, United States, ³Medical Physics, University of Wisconsin - Madison, Madison, WI, United States, ⁴Biomedical Engineering, University of Wisconsin - Madison, Madison, WI, United States, ⁵Medicine, University of Wisconsin - Madison, Madison, WI, United States, ⁶Emergency Medicine, University of Wisconsin - Madison, Madison, WI, United States

Spatially varying B1 inhomogeneities and tissue fat are known to be confounders of quantitative T1 mapping methods that use multiple flip-angle techniques. Separately acquired B1 calibration maps can be used to correct flip angle errors caused by B1 inhomogeneities, but this requires an additional acquisition. In this work we propose a comprehensive approach that combines concepts from actual flip-angle imaging with variable flip-angle imaging to simultaneously estimate B1 inhomogeneity, T1, proton density fat-fraction and R2*. The feasibility and noise performance of this joint acquisition and fitting approach are evaluated using Cramer-Rao Lower Bound analysis, simulations, phantom experiments, and preliminary in vivo examples.

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