Abstract #4894

Inversion Recovery Pointwise Encoding Time Reduction with Radial Acquisition (IR-PETRA) for Direct Myelin Imaging in Human Brain

Hyungseok Jang¹, Michael Carl², Yajun Ma¹, Yanjun Chen¹, Saeed Jerban¹, Eric Y Chang^1,3, and Jiang Du¹

¹Department of Radiology, University of California San Diego, San Diego, CA, United States, ²GE Healthcare, San Diego, CA, United States, ³Radiology Service, VA San Diego Healthcare System, San Diego, CA, United States

Due to very low proton density and rapid signal decay (T2*<300µs at 3T), it is challenging to directly image myelin in the white matter of the brain using MRI. The literature demonstrates that direct myelin imaging is feasible using inversion recovery (IR) preparation followed by dual echo ultrashort echo time (UTE) MRI, allowing direct capture of the rapidly-decaying myelin signal with greatly improved dynamic range. In this study, we show the efficacy of IR prepared Pointwise Encoding Time Reduction with Radial Acquisition (IR-PETRA) for direct myelin imaging in the human brain.

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