Abstract #4903

Analysis of Gradient Echo Myelin Water Imaging (GRE-MWI) for water exchange and scan parameters

Hyeong-Geol Shin¹, Se-Hong Oh², Joon Yul Choi¹, Kyeongseon Min¹, Hyunsung Eun¹, and Jongho Lee¹

¹Department of Electrical and Computer Engineering, Seoul National University, Seoul, Korea, Republic of, ²Biomedical Engineering, Hankuk University of Foreign Studies, Yongin, Korea, Republic of

In this study, we investigate the effects of the compartmental water exchange on gradient echo myelin water imaging (GRE-MWI). We simulate MWF variation from different scan parameters (flip angle and TR) using a four pool white matter model and compare the simulation results with the in-vivo measurements. The results demonstrate that 1) the simulation with the water exchange better explains the in-vivo results and 2) GRE-MWI with a long TR can provide robust myelin water quantification regardless of changes in flip angle. Therefore, our results suggest GRE-MWI with a long TR as a robust option for myelin water imaging.

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