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Abstract #4903

Analysis of Gradient Echo Myelin Water Imaging (GRE-MWI) for water exchange and scan parameters

Hyeong-Geol Shin1, Se-Hong Oh2, Joon Yul Choi1, Kyeongseon Min1, Hyunsung Eun1, and Jongho Lee1

1Department of Electrical and Computer Engineering, Seoul National University, Seoul, Korea, Republic of, 2Biomedical Engineering, Hankuk University of Foreign Studies, Yongin, Korea, Republic of

In this study, we investigate the effects of the compartmental water exchange on gradient echo myelin water imaging (GRE-MWI). We simulate MWF variation from different scan parameters (flip angle and TR) using a four pool white matter model and compare the simulation results with the in-vivo measurements. The results demonstrate that 1) the simulation with the water exchange better explains the in-vivo results and 2) GRE-MWI with a long TR can provide robust myelin water quantification regardless of changes in flip angle. Therefore, our results suggest GRE-MWI with a long TR as a robust option for myelin water imaging.

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