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Abstract #4904

Influence of model settings on myelin water fraction and frequency distribution for gradient-echo MRI at 7 Telsa

Kiran Thapaliya1, Viktor Vegh1, Steffen Bollmann1, and Markus Barth1

1The University of Queensland, Brisbane, Australia

Quantitative assessment of model parameters (water fraction and frequency shift) estimated using a multi-compartment model can be useful to study tissue properties in white matter. In this work, we utilise multi-compartment models for multi-echo gradient echo data acquired at 7T. We investigate the variation of model parameters that could potentially be affected by differences in tissue microstructure in the corpus callosum. We further study the effect of different models (number of compartments and parameters) on the estimation of tissue parameters. We show that the tissue parameters vary across the sub-regions of the corpus callosum and are effected by different modelling choices.

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