Abstract #4906

In vivo assessment of the anisotropy of R2* maps in white matter

Renat Sibgatulin¹, Andreas Deistung¹, Daniel Güllmar¹, Christoph Birkl², Stefan Ropele³, and Jürgen Rainer Reichenbach^1,4,5,6

¹Institute of Diagnostic and Interventional Radiology, Jena University Hospital – Friedrich Schiller University Jena, Jena, Germany, ²2 University of British Columbia, Vancouver, BC, Canada, ³Department of Neurology, Medical University of Graz, Graz, Austria, ⁴Michael Stifel Center for Data-driven and Simulation Science Jena, Friedrich Schiller University Jena, Jena, Germany, ⁵Abbe School of Photonics, Friedrich Schiller University Jena, Jena, Germany, ⁶Center of Medical Optics and Photonics, Friedrich Schiller University Jena, Jena, Germany

The effective transverse relaxation rate (R₂^*) is increasingly used in quantitative MRI, and its dependence on the orientation of white matter fibers in the brain has received significant attention. In this contribution, we assess the effect of the flip angle of a multi-echo gradient-echo sequence on the orientation dependence of the derived R₂^* map and suggest a simplified explanation to the observed R₂^*(θ; FA) behavior.

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