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Abstract #4906

In vivo assessment of the anisotropy of R2* maps in white matter

Renat Sibgatulin1, Andreas Deistung1, Daniel Güllmar1, Christoph Birkl2, Stefan Ropele3, and Jürgen Rainer Reichenbach1,4,5,6

1Institute of Diagnostic and Interventional Radiology, Jena University Hospital – Friedrich Schiller University Jena, Jena, Germany, 22 University of British Columbia, Vancouver, BC, Canada, 3Department of Neurology, Medical University of Graz, Graz, Austria, 4Michael Stifel Center for Data-driven and Simulation Science Jena, Friedrich Schiller University Jena, Jena, Germany, 5Abbe School of Photonics, Friedrich Schiller University Jena, Jena, Germany, 6Center of Medical Optics and Photonics, Friedrich Schiller University Jena, Jena, Germany

The effective transverse relaxation rate (R2*) is increasingly used in quantitative MRI, and its dependence on the orientation of white matter fibers in the brain has received significant attention. In this contribution, we assess the effect of the flip angle of a multi-echo gradient-echo sequence on the orientation dependence of the derived R2* map and suggest a simplified explanation to the observed R2*(θ; FA) behavior.

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