Abstract #4908

Evaluating the sensitivity of T1w/T2w, MTR, MWF and DKI to variation of myelin content

Run Pu¹, Hongjian He¹, Zhe Wu², Yi Sun³, and Jianhui Zhong^1,4

¹Center for Brain Imaging Science and Technology, Key Laboratory for Biomedical Engineering of Ministry of Education, College of Biomedical Engineering and Instrumental Science, Zhejiang University, HangZhou, China, ²Department of Neurology and Neurosurgery, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada, ³MR Collaboration, Siemens Healthcare Ltd., Shanghai, China, ⁴Department of Imaging Sciences, University of Rochester, Rochester, NY, United States

MRI metrics such as T1w/T2w ratio, magnetization transfer ratio (MTR), myelin water faction (MWF) and diffusion kurtosis imaging (DKI) indices have been used to detect myelin content. To assess the sensitivity of above metrics to variation of myelin content, in vivo human corpus callosum is used as a test case in the study. The results suggest that MTR varies least but MWF varies the most as myelin content changes.

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