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Abstract #4910

Apparent Population Inversion Due to Steady-State Transcytolemmal Water Exchange

Xin Li1, Silvia Mangia2, Jing-Huei Lee3, Ruiliang Bai4, and Charles S. Springer1

1Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States, 2Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, 3Biomedical Engineering, University of Cincinnati, Cincinnati, OH, United States, 4Interdisciplinary Institute of Neuroscience and Technology, Zhejiang University, Hangzhou, China

The homeostatic cellular water efflux rate constant, kio, has a significant contribution from cell membrane sodium pump activity previously unmeasurable. With high extracellular contrast agent concentration or ultra-low magnetic field, kio can be precisely determined by two-site-exchange analysis of in vivo 1H2O longitudinal relaxation data. With the low field case, there is an inversion of the apparent tissue compartmental contributions from the true values. The NMR shutter-speed organizing principle informs an analysis spanning the entire range of conditions.

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