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Abstract #4912

In vivo inhomogeneous magnetization transfer (ihMT) outside the brain using radial ultra-short echo-time acquisitions

Gopal Varma1, Cody Callahan1, Olivier M Girard2, Guillaume Duhamel2, Aaron K Grant1, and David C Alsop1

1Radiology, Division of MR Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States, 2Aix Marseille Univ, CNRS, CRMBM, Marseille, France

Inhomogeneous magnetization transfer (ihMT) effects have been readily observed in myelinated structures. The advent of low duty-cycle ihMT to increase the signal allows application of ihMT in other tissues. In this work, we explore the feasibility of applying ihMT in non-myelinated tissues such as the heart, liver, and kidneys of mice. This is achieved using a radial, ultra-short echo-time acquisition for greater motion robustness. The results demonstrate a measurable ihMT signal outside the central nervous system. Thus the microstructure of such tissues might be assessed based on the dipolar order contribution to ihMT.

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