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Abstract #4913

Myelin-sensitive imaging of the optic chiasm and optic nerve at 3T using inhomogeneous magnetization transfer (ihMT) with high B1 pulses

Ece Ercan1, Fang Yu1, Ivan E. Dimitrov2,3, Gopal Varma4, David C. Alsop4, Robert E. Lenkinski1,2, and Elena Vinogradov1,2

1Department of Radiology, UT Southwestern Medical Center, Dallas, TX, United States, 2Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States, 3Philips Healthcare, Gainesville, FL, United States, 4Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States

Inhomogeneous magnetization transfer (ihMT) imaging is a novel enhanced magnetization transfer contrast, which has been shown to originate from long-lived dipolar couplings in the tissue (e.g. dipolar couplings between the methylene molecules of the myelin phospholipid bilayer). In this study, we optimized an ihMT scan protocol for imaging the optic nerve and chiasm for the first time. This method may potentially be used for quantitative evaluation of patients with multiple sclerosis (MS), as well as other diseases affecting the visual pathway.

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