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Abstract #4917

On the dipolar order underlying broad macromolecular lines

Olivier M. Girard1, Victor N.D. Carvalho1, Ludovic de Rochefort1, Andreea Hertanu1, Pierre Thureau2, Gopal Varma3, David Alsop3, and Guillaume Duhamel1

1Aix Marseille Univ, CNRS, CRMBM, Marseille, France, 2Aix Marseille Univ, CNRS, ICR, Marseille, France, 3Division of MR Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States

Dipolar order has recently regained attention in MRI to analyze dipolar broadened lines in CEST and inhomogeneous Magnetization Transfer (ihMT), leading to new frequency irradiation patterns for enhanced saturation and access to an unexplored degree of freedom. A better understanding of dipolar order is of great interest to guide intuition and may lead to fundamental optimization of the ihMT technique, which is a promising tool providing new tissue contrasts. In this contribution we propose to review this concept, considering a simplified model of isolated proton pairs and the general Provotorov theory of RF saturation which applies to an ensemble of coupled spin.

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