Myelin is essential component for complex motor, sensory and cognition function.1 Among many quantitative magnetic resonance imaging (MRI) techniques investigating myelin structure, direct MR parameter influenced by the myelin thickness is rarely investigated.1 Here, we study the effect of myelin thickness on R2, R2* and susceptibility using the finite perturber method (FPM)-based simulation and post-mortem aging rat brains. It is observed from simulations that both myelin thickness and myelin volume fraction (MVF) affects R2 and R2* values, whereas the phase change (QSM) showed a significant change only by the change of MVF. In preliminar experiments, consistent results were observed.
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