Abstract #4924

Altered Brain Iron Content and Deposition Rate in Huntington Disease Indicated by Quantitative Susceptibility MRI

Lin Chen^1,2,3, Jun Hua^1,2, Christopher A. Ross⁴, Shuhui Cai³, Peter C.M. van Zijl^1,2, and Xu Li^1,2

¹Department of Radiology and Radiological Sciences, Johns Hopkins University, BALTIMORE, MD, United States, ²F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, BALTIMORE, MD, United States, ³Department of Electronic Science, Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance, Xiamen, China, ⁴Department of Psychiatry, Division of Neurobiology, and Departments of Neurology, Neuroscience and Pharmacology,Johns Hopkins University, BALTIMORE, MD, United States

We investigated the natural history of brain iron content at different stages of premanifest and manifest Huntington disease (HD) as indicated by changes of magnetic susceptibility values measured by quantitative susceptibility mapping (QSM). Higher susceptibilities were observed in striatum and globus pallidus of closer-to-onset premanifest HD and early HD patients, but not in the further-from-onset premanifest HD group as compared to controls using 1-way MANCOVA. Analysis using a general linear model showed significantly higher iron deposition rates (11.9%/yr in caudate and 6.1%/yr in globus pallidus) in closer-to-onset premanifest HD and early HD as compared to controls over a one-year follow-up.

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