Abstract #4930

Evaluating the Relationship Between the Venous Magnetic Susceptibility ($$$\chi$$$) and $$$R_2^*$$$ of Brain Arteriovenous Malformations (AVMs)

Emma Biondetti¹, Alvaro Rojas Villabona², Hans Rolf Jäger², David L. Thomas^2,3, and Karin Shmueli¹

¹Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, ²Neuroradiological Academic Unit, UCL Institute of Neurology, University College London, London, United Kingdom, ³Leonard Wolfson Experimental Neurology Centre, UCL Institute of Neurology, University College London, London, United Kingdom

Arteriovenous malformations (AVMs) are characterised by arteriovenous shunting, which increases oxygenation in the veins draining the AVM compared to healthy veins. In healthy veins, a quadratic relationship is expected between the transverse relaxation rate ($$$R_2^*$$$) and the magnetic susceptibility ($$$\chi$$$). By calculating $$$\chi$$$ and $$$R_2^*$$$ we investigated whether this relationship holds in the AVM draining veins and superior sagittal sinuses of fourteen patients. We found a significant positive correlation between $$$R_2^*$$$ and $$$\chi^2$$$ in the healthy veins, but not in the AVM draining veins where the quadratic relationship is disrupted and $$$\chi$$$ values can be used to measure oxygenation.

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