Abstract #4935

Measurement of Copper and Iron Accumulation in the Deep Gray Matter Nuclei of patients with Wilson Disease Using Quantitative Susceptibility Mapping and R2* Mapping

Gaiying Li¹, Rong Wu², Rui Tong¹, Zhe Liu³, Pascal Spincemaille³, Kelly M Gillen³, Yi Wang^1,3, Xiaoping Wang², and Jianqi Li¹

¹East China Normal University, Shanghai, China, ²Shanghai First People Hospital, Shanghai, China, ³Weill Medical College of Cornell University, New York, NY, United States

The objective of this study was to evaluate magnetic susceptibility and R2* values from QSM and R2* for differentiating Wilson Disease (WD) from healthy controls (HC). 14 WD and 14 HC subjects were scanned using a 3D multi-echo GRE sequence. The results indicated that susceptibility values in the caudate nucleus (CN), putamen (PUT), globus pallidus (GP), substantia nigra (SN), red nucleus (RN) were significantly higher in patients with WD as compared to those of HC. R2* values were significantly higher in WD patients in all ROIs. Receiver operating characteristic analysis showed that QSM provided the highest AUC=0.888 at SN.

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