Abstract #4941

Dynamic quantitative susceptibility mapping to assess vascular compliance in the brain

Christoph Birkl^1,2, Christian Langkammer², Pascal Sati³, Christian Enzinger², Franz Fazekas², and Stefan Ropele²

¹UBC MRI Research Centre, University of British Columbia, Vancouver, BC, Canada, ²Department of Neurology, Medical University of Graz, Graz, Austria, ³Translational Neuroradiology Unit, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States

In this study we explored if quantitative susceptibility mapping (QSM) allows assessing blood pressure induced changes of the magnetic susceptibility in the brain as consequence of cerebral autoregulation. Eight healthy subjects underwent fast QSM at 3.0-T and simultaneous measurement of the mean arterial pressure (MAP) following a small drop in MAP caused by a change in posture. A linear relationship between MAP and susceptibility was observed, where the slope represents a measure of the cerebral vascular compliance with different signs for arterial and venous blood vessels.

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