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Abstract #4944

Cerebral spin compartmentalization based on biexponential modeling of T2-prepared pCASL 3D GRASE data

Martin Schidlowski1,2, Markus Boland2, Theodor Rüber1, and Tony Stöcker2,3

1Department of Epileptology, University of Bonn Medical Center, Bonn, Germany, 2German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany, 3Department of Physics and Astronomy, University of Bonn, Bonn, Germany

In this work, a pCASL sequence with T2 preparation module and 3D GRASE readout was developed. We present a novel approach to estimate the spin compartment of labeled protons by a voxel-wise and biexponential fit to whole-brain ASL data. This method allows for the spatial quantification of intra- and extravascular spin fractions of the ASL signal as well as their temporal evolution.

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