Abstract #4944

Cerebral spin compartmentalization based on biexponential modeling of T2-prepared pCASL 3D GRASE data

Martin Schidlowski^1,2, Markus Boland², Theodor Rüber¹, and Tony Stöcker^2,3

¹Department of Epileptology, University of Bonn Medical Center, Bonn, Germany, ²German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany, ³Department of Physics and Astronomy, University of Bonn, Bonn, Germany

In this work, a pCASL sequence with T2 preparation module and 3D GRASE readout was developed. We present a novel approach to estimate the spin compartment of labeled protons by a voxel-wise and biexponential fit to whole-brain ASL data. This method allows for the spatial quantification of intra- and extravascular spin fractions of the ASL signal as well as their temporal evolution.

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