Abstract #4943

Readout Duration-dependent Bias on R2* Mapping and Quantitative Susceptibility Mapping Using 3D Radial and Cones Acquisitions at 3.0T

Shihan Qiu¹, Timothy J. Colgan², Ante Zhu^2,3, Kevin M. Johnson^2,4, Scott B. Reeder^2,3,4,5,6, and Diego Hernando^2,4

¹Biomedical Engineering, Tsinghua University, Beijing, China, ²Radiology, University of Wisconsin, Madison, WI, United States, ³Biomedical Engineering, University of Wisconsin, Madison, WI, United States, ⁴Medical Physics, University of Wisconsin, Madison, WI, United States, ⁵Medicine, University of Wisconsin, Madison, WI, United States, ⁶Emergency Medicine, University of Wisconsin, Madison, WI, United States

Ultra-short TE (UTE) R2* mapping and Quantitative Susceptibility Mapping (QSM) are emerging techniques for quantifying iron deposition in various organs, including the brain and liver. In tissues with short T2* values (high R2*), the fast signal decay-induced errors during the relatively long readout in typical UTE acquisitions, i.e., 3D radial and cones UTE, may confound R2* and susceptibility measurements. In this study, we characterized the readout duration effects on R2* and susceptibility estimation in 3D radial and cones UTE-acquisitions at 3.0T. Simulation and phantom studies showed bias in the estimated R2* and susceptibility when long readout durations were used.

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