Abstract #4946

Robust arterial transit time estimation using combined acquisition of Hadamard-encoded pCASL and long-labeled long-delay pCASL: a simulation and in vivo study

Shota Ishida^1,2, Hirohiko Kimura³, Naoyuki Takei⁴, Yasuhiro Fujiwara⁵, Tsuyoshi Matsuda⁶, Masayuki Kanamoto¹, Nobuyuki Kosaka³, R Marc Lebel⁷, and Toshiki Adachi¹

¹Radiological Center, University of Fukui Hospital, Yoshida-gun, Japan, ²Division of Health Sciences, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan, ³Department of Radiology, Faculty of Medical Sciences, University of Fukui, Yoshida-gun, Japan, ⁴MR applications and Workflow, GE Healthcare Japan, Hino, Japan, ⁵Department of Medical Imaging, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan, ⁶Division of Ultrahigh Field MRI, Institute for Biomedical Science, Iwate Medical University, Shiwa-gun, Japan, ⁷MR Applications and Workflow, GE Healthcare, Calgary, AB, Canada

A combination scan of 3-delay Hadamard-encoded pseudo-continuous ASL (H-pCASL) and single-delay pCASL with long labeling duration and long post-labeling delay was proposed as the robust arterial transit time (ATT) estimation for prolonged ATTs. Simulation showed that the mean normalized error of the proposed method was small for a wide range of ATTs compared to that of H-pCASL alone. In in vivo experiments, ATTs were not significantly different among the methods. However, 7-delay H-pCASL presented a lower ATT and larger variance. The proposed method improves the robustness of ATT estimation for prolonged ATTs with practical acquisition times in the clinical framework.

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