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Abstract #4946

Robust arterial transit time estimation using combined acquisition of Hadamard-encoded pCASL and long-labeled long-delay pCASL: a simulation and in vivo study

Shota Ishida1,2, Hirohiko Kimura3, Naoyuki Takei4, Yasuhiro Fujiwara5, Tsuyoshi Matsuda6, Masayuki Kanamoto1, Nobuyuki Kosaka3, R Marc Lebel7, and Toshiki Adachi1

1Radiological Center, University of Fukui Hospital, Yoshida-gun, Japan, 2Division of Health Sciences, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan, 3Department of Radiology, Faculty of Medical Sciences, University of Fukui, Yoshida-gun, Japan, 4MR applications and Workflow, GE Healthcare Japan, Hino, Japan, 5Department of Medical Imaging, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan, 6Division of Ultrahigh Field MRI, Institute for Biomedical Science, Iwate Medical University, Shiwa-gun, Japan, 7MR Applications and Workflow, GE Healthcare, Calgary, AB, Canada

A combination scan of 3-delay Hadamard-encoded pseudo-continuous ASL (H-pCASL) and single-delay pCASL with long labeling duration and long post-labeling delay was proposed as the robust arterial transit time (ATT) estimation for prolonged ATTs. Simulation showed that the mean normalized error of the proposed method was small for a wide range of ATTs compared to that of H-pCASL alone. In in vivo experiments, ATTs were not significantly different among the methods. However, 7-delay H-pCASL presented a lower ATT and larger variance. The proposed method improves the robustness of ATT estimation for prolonged ATTs with practical acquisition times in the clinical framework.

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