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Abstract #4950

Quantification of intracranial vascular compliance using multi-PLD pseudo-continuous arterial spin labeling with retrospective cardiac gating

Soroush Heidari Pahlavian1,2, Mayank Jog1,2, Samantha Ma1,2, Danny J.J. Wang1,2, and Lirong Yan1,2

1Laboratory of FMRI Technology (LOFT), Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, 2Department of Neurology, University of Southern California, Los Angeles, CA, United States

Intracranial vascular compliance (IVC) is an important factor in regulating the cerebral perfusion pressure and is believed to be linked to multiple neurological disorders. In this study, a retrospectively-gated multi-PLD pCASL technique was used to estimate arterial cerebral blood volume (aCBV) and compliance. Our results showed that this technique can quantify cardiac-induced variations of aCBV as well as IVC distribution maps.

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