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Abstract #4949

Enabling free-breathing renal pCASL with background suppression and motion correction: a comparison with paced-breathing

Isabell K. Bones1, Anita A. Harteveld1, Suzanne L. Franklin1,2, Matthias J.P. van Osch2, Jeroen Hendrikse3, Chrit Moonen1, Clemens Bos1, and Marijn van Stralen1

1Center for Image Sciences, University Medical Center Utrecht, Utrecht, Netherlands, 2C.J.Gorter Center for High Field MRI, Leiden University Medical Center, Leiden, Netherlands, 3Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands

Renal perfusion imaging using arterial spin labeling (ASL) is challenged by respiratory motion and physiologic noise, often dealt with by breathing instructions requiring patient cooperation. We investigated if background suppression (BGS) combined with image registration, guided by the ASL-images themselves or additionally acquired fat-images, would enable free-breathing renal ASL. To this end, free-breathing ASL was compared with paced-breathing ASL, both including BGS and image registration. BGS and registration improved the quality of free-breathing renal pCASL, showing increased temporal SNR similar to paced-breathing ASL, without reducing perfusion-weighted signal. In conclusion, free-breathing renal pCASL is possible when employing BGS and image registration.

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