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Abstract #4953

Beyond the consensus: what to include when 5 minutes are available for perfusion imaging by PCASL?

Piet Bladt1, Matthias JP van Osch2,3, Eric Achten4, Arnold J den Dekker1,5, and Jan Sijbers1

1imec - Vision Lab, Department of Physics, University of Antwerp, Antwerp, Belgium, 2Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, 3Leiden Institute of Brain and Cognition, Leiden University, Leiden, Netherlands, 4Department of Radiology and Nuclear Medicine, Ghent University, Ghent, Belgium, 5Delft Center for Systems and Control, Delft University of Technology, Delft, Netherlands

While the consensus statement on the recommended implementation of arterial spin labeling (ASL) has advanced ASL to clinical application, variations in labeling efficiency, longitudinal relaxation time of blood and arterial transit times can cause significant quantification errors. With simulation experiments, it is shown that sacrificing ASL scan time for measurements of these parameters improves the estimation reproducibility of the cerebral blood flow on a population level. Furthermore, multi-delay ASL modalities in combination with these extra measurements can compete with or outperform the single-delay consensus implementation in terms of estimation accuracy and precision, depending on the underlying distribution of transit times.

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