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Abstract #4958

Arterial spin labeling reveals altered cerebral vascular reactivity to carbon dioxide challenge in Q175 mouse model of Huntington's disease

Somaie Salajeghe1, Johan Van Audekerke1, Verdi Vanreusel1, Dorian Pustina2, Longbin Liu2, Mette Skinbjerg2, Celia Dominguez2, Ignacio Munoz-Sanjuan2, Annemie Van der Linden1, and Marleen Verhoye1

1Bio-Imaging lab,University of Antwerp, Antwerp, Belgium, 2CHDI Foundation, Princeton, NJ, United States

CVR deficits can cause a negative effect on neurovascular coupling leading to blood delivery impairment in activated brain regions. As such, impaired CVR may lead to neural degeneration over a period of time. We measured CBF and CVR using pCASL in Q175 mouse model of Huntington’s disease (11 transgenic and 10 wild-type at 15 month). In order to measure CVR, we measured changes in CBF during a 10% CO2 vascular challenge. The results indicated an overall decreased CVR in transgenic compared to wild-type mice.

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