Abstract #4958

Arterial spin labeling reveals altered cerebral vascular reactivity to carbon dioxide challenge in Q175 mouse model of Huntington's disease

Somaie Salajeghe¹, Johan Van Audekerke¹, Verdi Vanreusel¹, Dorian Pustina², Longbin Liu², Mette Skinbjerg², Celia Dominguez², Ignacio Munoz-Sanjuan², Annemie Van der Linden¹, and Marleen Verhoye¹

¹Bio-Imaging lab,University of Antwerp, Antwerp, Belgium, ²CHDI Foundation, Princeton, NJ, United States

CVR deficits can cause a negative effect on neurovascular coupling leading to blood delivery impairment in activated brain regions. As such, impaired CVR may lead to neural degeneration over a period of time. We measured CBF and CVR using pCASL in Q175 mouse model of Huntington’s disease (11 transgenic and 10 wild-type at 15 month). In order to measure CVR, we measured changes in CBF during a 10% CO₂ vascular challenge. The results indicated an overall decreased CVR in transgenic compared to wild-type mice.

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