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Abstract #4957

Investigation of the effects of age and gender on normal cerebral blood flow in infants using arterial spin labeling MRI

KEKE ZHAO1, ZHUANQIN REN2, and Xiaocheng Wei3

1Shaanxi University of Chinese Medicine, Xianyang, China, 2Baoji Center Hospital, Baoji, China, 3GE Healthcare China, Beijing, China

This study systematically revealed normal values of cerebral blood flow (CBF) in different age groups of infants using three-dimensional pseudocontinuous arterial spin labeling (3D PCASL) technique. Our results demonstrated a significantly lower CBF value in neonates than in other age groups. We also found a significant positive correlation between age and various regional mean gray matter (GM) and white matter (WM) CBF values in infants. Taken together, our findings demonstrated benefits of the application of the infants perfusion imaging technology to the clinical field by using arterial spin labeling (ASL) to provide information of metabolic status and neurodevelopmental outcomes.

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