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Abstract #4961

Assessing Morphology of Cerebral Macro- and Microvasculature Using Dynamic Perfusion Tensor Imaging ASL

Leonie Petitclerc1, Suzanne Franklin1,2, Lydiane Hirschler1, and Matthias van Osch1

1C.J. Gorter Center for High Field MRI, Radiology, Leiden University Medical Center, Leiden, Netherlands, 2Center for Image Sciences, University Medical Center Utrecht, Utrecht, Netherlands

Time-encoded pseudo-continuous ASL was combined with bipolar crusher gradients to measure a time-resolved perfusion tensor of the brain vasculature. Gradients provided a high degree of attenuation of the intravascular signal which increased with greater gradient strength and decreased (down to 25%) at long post-labeling delays (PLDs). Perfusion tensor images showed correspondence with known structures such as the anterior cerebral artery and the circle of Willis. Fractional anisotropy of perfusion remained elevated and increased with longer PLDs. Adjustments in gradient strength and time-encoding scheme may permit the imaging of microvascular structure.

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