Quantification of T2 values is valuable for a broad range of pathologies, yet, highly challenging due to the contamination of rapid multi-echo spin-echo (MESE) protocols by stimulated and indirect echoes. Bloch-simulations based methods, such as the echo modulation curve (EMC) algorithm, take these signal fluctuations into account and produce accurate, precise, and reproducible T2 values. This work provides detailed analysis of magnetization transfer (MT) effect on MESE signal and on the ensuing T2 values, investigating different protocol settings, and using three models: in vitro urea phantom, ex vivo horse brain and in vivo human brain.
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