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Abstract #4989

Analysis of magnetization transfer (MT) influence on quantitative mapping of T2 relaxation time

Dvir Radunsky1, Tamar Blumenfeld-Katzir1, Osnat Volovyk2, Tal Assaf2, Daniel Barazany3, Galia Tsarfaty4, and Noam Ben-Eliezer1,5,6

1Department of Biomedical Engineering, Tel Aviv University, Tel Aviv, Israel, 2Department of Chemical Physics, The Weizmann Institute, Rehovot, Israel, 3Strauss computational neuroimaging center, Faculty of Life sciences, Tel Aviv University, Tel Aviv, Israel, 4Department of Diagnostic Imaging, Sheba Medical Center, Ramat Gan, Israel, 5Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel, 6Center for Advanced Imaging Innovation and Research (CAI2R), New-York University Langone Medical Center, New York, NY, United States

Quantification of T2 values is valuable for a broad range of pathologies, yet, highly challenging due to the contamination of rapid multi-echo spin-echo (MESE) protocols by stimulated and indirect echoes. Bloch-simulations based methods, such as the echo modulation curve (EMC) algorithm, take these signal fluctuations into account and produce accurate, precise, and reproducible T2 values. This work provides detailed analysis of magnetization transfer (MT) effect on MESE signal and on the ensuing T2 values, investigating different protocol settings, and using three models: in vitro urea phantom, ex vivo horse brain and in vivo human brain.

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