Abstract #4993

Simultaneous Concentration Quantification of SPIO and ProHance using bSSFP MR Fingerprinting

Ollie Marriott^1,2, Chris V Bowen^1,2, James A Rioux^1,2, and Kimberley D Brewer^1,2

¹Biomedical Translational Imaging Centre (BIOTIC), Halifax, NS, Canada, ²Department of Physics & Atmospheric Science, Dalhousie University, Halifax, NS, Canada

Superparamagnetic Iron Oxide (SPIO) contrast agents are used extensively in molecular imaging studies as a tool to evaluate various cell types. Enabling simultaneous use of multiple contrast agents would greatly improve molecular imaging studies. We utilize a bSSFP MR fingerprinting sequence, combined with an extension of the concentration-dependent linear relationship, to show that concentrations of SPIO and a second contrast agent (ProHance) can be simultaneously quantified.

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