Abstract #4994

Characterization of brown adipose tissue in PCOS patients by Z-Spectrum Imaging (ZSI)

Li LI^1,2, Alessandro Scotti², Jicheng Fang¹, Chong Wee Liew³, Nael Khayyat⁴, WenZhen Zhu¹, and Kejia Cai²

¹Radiological Department, Tongji Hospital, Tongji Medical College, HUST, Wuhan, China, ²1.Radiology Dept., 2. Bioengineering Dept., College of Medicine, University of Illinois at Chicago, Chicago, IL, United States, ³Dept. of Physiology & biophysics, College of Medicine, University of Illinois at Chicago, Dept. of Physiology & biophysics, Chicago, IL, United States, ⁴Department of Radiology, College of Medicine, University of Illinois at Chicago, Department of Radiology, College of Medicine, University of Illinois at Chicago, Chicago, IL, United States

Z-spectrum imaging (ZSI) was used to characterize brown adipose tissue (BAT) features in polycystic ovary syndrome (PCOS) patients compared to healthy subjects. Fat-water fraction (FWF) was derived from the fitting of the direct saturation of water and fat in ZSI. BAT segmentation allowed the measurement of BAT-specific FWF and area. PCOS group showed increased FWF and reduced BAT area compared to controls, likely due to reduced BAT cells activity and lipid accumulation. ZSI can therefore be used to study BAT characteristics in vivo in metabolic disorders.

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