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Abstract #4999

Dynamic Glucose Enhanced Imaging at 3T: Effects of Physiological Changes and Motion

Xiang Xu1,2, Anina Seidemo3, Akansha A Sehgal1,2, Nirbhay N Yadav1,2, Moritz Zaiss4, Linda Knutsson1,3, and Peter C.M. van Zijl1,2

1Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States, 2F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, United States, 3Department of Medical Radiation Physics, Lund University, Lund, Sweden, 4High-field Magnetic Resonance Center, Max Planck Institute for Biological Cybernetics, Tubingen, Germany

Dynamic glucose enhanced (DGE) MRI has shown potential for imaging D-glucose delivery and brain uptake at fields of 7T and higher. Here we evaluate some issues involved with translating DGE MRI to the clinical field strength of 3T. Due to the reduced effect size subject motion becomes more confounding than at 7T, possibly producing artifacts in terms of dynamic signal changes that are beyond the magnitude of the actual effect size. On the other hand, physiological changes such as ventricular swelling and vascular dilatation may appear as motion to the motion correction procedure, possibly leading to unintended overcorrection.

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