Chemical exchange saturation transfer (CEST) is an MRI technique sensitive to the presence of low-concentration solute protons exchanging with water. However, magnetization transfer (MT) effects due to large macromolecules also exchange with water, and they can bias potential CEST effects if they are not correctly modelled. This study demonstrates that simultaneously modelling CEST and MT may yield incorrect estimates of CEST effects if an insufficient model is utilised. To prevent this, the MT effect should first be quantified outside the CEST domain and subsequently applied to CEST analyses.
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