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Abstract #5000

Does the MT Effect Bias CEST Effects? Quantifying CEST in the Presence of MT

Alex K. Smith1, Kevin J. Ray1, Martin Craig2, Seth A. Smith3, and Michael A Chappell2

1Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, United Kingdom, 2Institute of Biomedical Engineering, Department of Engineering Sciences, University of Oxford, Oxford, United Kingdom, 3Vanderbilt University Institute of Imaging Sciences, Vanderbilt University, Nashville, TN, United States

Chemical exchange saturation transfer (CEST) is an MRI technique sensitive to the presence of low-concentration solute protons exchanging with water. However, magnetization transfer (MT) effects due to large macromolecules also exchange with water, and they can bias potential CEST effects if they are not correctly modelled. This study demonstrates that simultaneously modelling CEST and MT may yield incorrect estimates of CEST effects if an insufficient model is utilised. To prevent this, the MT effect should first be quantified outside the CEST domain and subsequently applied to CEST analyses.

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