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Abstract #5001

Quantification of brain perfusion using dynamic glucose-enhanced MRI

Charlotte Debus1,2, Patrick Schuenke3,4, Ralf Floca2,5, Myriam Keymling6, Amir Abdollahi1,2, Alexander Radbruch6, Peter Bachert4,7, Mark E Ladd4,7,8, Heinz-Peter Schlemmer6, and Daniel Paech6

1Translational Radiation Oncology, National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ), Heidelberg, Germany, 2Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), Heidelberg, Germany, 3Leibniz-Forschungsinstitut für Molekulare Pharmakologie, Berlin, Germany, 4Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 5Division of Medical Image Computing, German Cancer Research Center (DKFZ), Heidelberg, Germany, 6Division of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 7Faculty of Physics and Astronomy, University of Heidelberg, Heidelberg, Germany, 8Faculty of Medicine, University of Heidelberg, Heidelberg, Germany

Dynamic glucose-enhanced (DGE) MRI was analyzed to derive quantitative parameters related to tissue perfusion, microvasculature and glucose uptake in the human brain. Adiabatically prepared T1ρ-weighted DGE-MRI was performed on seven healthy volunteers and one glioblastoma patient with a 7T scanner after administration of D-glucose. DGEρ time curves were investigated in different morphological structures of the healthy brain and in tumor tissue by extraction of semi-quantitative parameters and pharmacokinetic modelling using the extended Tofts model. Results show that application of semi-quantitative and pharmacokinetic modeling approaches for quantification of DGE-MRI is feasible in both healthy humans and brain tumor patients.

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