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Abstract #5003

Model-free generation of CEST contrast using principal components of Z-spectra at 3 T

Anagha Deshmane1, Moritz Zaiss1, Mark Schuppert1, Kai Herz1, and Klaus Scheffler1

1High-field magnetic resonance center, Max Planck Institute for biological cybernetics, Tübingen, Germany

Fitting of spectrally selective CEST contrasts requires models with limiting assumptions. Snapshot CEST allows us to densely sample the Z-spectrum with rapid volumetric imaging within a clinically feasible scan time. With over 60k spectra available per subject, statistically-driven analysis methods are now possible. Here we demonstrate that principle component analysis can be used for model-free analysis of spectral features. Projection of Z-spectra onto principle components from a group of healthy subjects provides several relevant contrasts which reveal anatomical detail and correlate with Gadolinium uptake signatures in a brain tumor patient.

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