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Abstract #5007

A comparison of dynamic and static B0 mapping approaches for correction of CEST MRI at 7T

Esau Poblador Rodriguez1, Philipp Moser1, Barbara Dymerska2, Simon Robinson1, Benjamin Schmitt3, Andre van der Kouwe4, Stephan Gruber1, Siegfried Trattnig1,5, and Wolfgang Bogner1

1High Field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 2Medical Physics and Bioengineering, University College London, London, United Kingdom, 3Siemens Healthineers, Sydney, Australia, 4Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States, 5Christian Doppler Laboratory for Clinical Molecular MR Imaging, Vienna, Austria

In contrast to established static B0 correction approaches which assume an invariant static field during a CEST MRI acquisition, we propose three methods which can track and compensate temporal B0 fluctuations by shifting each Z-spectral point separately before MTRasym analysis. We show the benefit of the proposed dynamic methods in comparison to three established static approaches by assessing their performance in the absence/presence of an induced frequency drift. In addition, we investigate the reliability and reproducibility of CEST MRI at ultra-high field (7T) by evaluating the drift’s impact on the B0-corrected MTRasym maps in the brains of five healthy volunteers.

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