Abstract #5007

A comparison of dynamic and static B0 mapping approaches for correction of CEST MRI at 7T

Esau Poblador Rodriguez¹, Philipp Moser¹, Barbara Dymerska², Simon Robinson¹, Benjamin Schmitt³, Andre van der Kouwe⁴, Stephan Gruber¹, Siegfried Trattnig^1,5, and Wolfgang Bogner¹

¹High Field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, ²Medical Physics and Bioengineering, University College London, London, United Kingdom, ³Siemens Healthineers, Sydney, Australia, ⁴Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States, ⁵Christian Doppler Laboratory for Clinical Molecular MR Imaging, Vienna, Austria

In contrast to established static B₀ correction approaches which assume an invariant static field during a CEST MRI acquisition, we propose three methods which can track and compensate temporal B₀ fluctuations by shifting each Z-spectral point separately before MTR_asym analysis. We show the benefit of the proposed dynamic methods in comparison to three established static approaches by assessing their performance in the absence/presence of an induced frequency drift. In addition, we investigate the reliability and reproducibility of CEST MRI at ultra-high field (7T) by evaluating the drift’s impact on the B₀-corrected MTR_asym maps in the brains of five healthy volunteers.

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