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Abstract #5009

Acquisition protocol for glucoCESL MRI in the human brain at 7T with reduced motion-induced artifacts

Philip S. Boyd1, Johannes Breitling1, Ferdinand Zimmermann1, Andreas Korzowski1, Moritz Zaiss2, Kai Herz2, Patrick Schuenke1, Nina Weinfurtner3, Heinz-Peter Schlemmer3, Mark E. Ladd1, Peter Bachert1, Daniel Paech3, and Steffen Goerke1

1Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 2High‐field Magnetic Resonance Center, Max Planck Institute for Biological Cybernetics, Tübingen, Germany, Tübingen, Germany, 3Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

In this study, an acquisition protocol for glucoCESL MRI examinations in the human brain is presented, that was optimized for suppression of motion-induced artifacts. This was achieved by using a combination of (i) a 3D imaging readout, which enabled co-registration of the acquired images over the course of time, and (ii) a ΔR contrast based on quantitative R maps instead of R-weighted images. The presented acquisition protocol improves the applicability of glucose-weighted MRI for examinations in humans where motion is present. Feasibility was verified by examination in a first patient with glioblastoma.

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