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Abstract #5010

Investigating Gadolinium Depositions in Glycosaminoglycans using CEST MRI - Why T1 Corrections are Important

Patrick Schuenke1, Patrick Werner1, Matthias Taupitz2, and Leif Schröder1

1Leibniz-Institut für Molekulare Pharmakologie (FMP), Berlin, Germany, 2Department of Radiology, Charité - Universitätsmedizin Berlin, Berlin, Germany

In this study, we investigated the CEST effect of model solutions composed of gadolinium-based contrast agents (GdCA), heparin as model substance for glycosaminoglycans (GAGs) and ZnCl2 with the aim to provide direct evidence of Gd3+-GAG complex formations. We performed time resolved CEST and T1 relaxation time measurements and quantified the CEST effects using different CEST metrics, including MTRasym and AREX. Our results demonstrate the necessity of T1 correction in CEST MRI in such a case where T1 conditions are affected, too.

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