Abstract #5010

Investigating Gadolinium Depositions in Glycosaminoglycans using CEST MRI - Why T1 Corrections are Important

Patrick Schuenke¹, Patrick Werner¹, Matthias Taupitz², and Leif Schröder¹

¹Leibniz-Institut für Molekulare Pharmakologie (FMP), Berlin, Germany, ²Department of Radiology, Charité - Universitätsmedizin Berlin, Berlin, Germany

In this study, we investigated the CEST effect of model solutions composed of gadolinium-based contrast agents (GdCA), heparin as model substance for glycosaminoglycans (GAGs) and ZnCl₂ with the aim to provide direct evidence of Gd³⁺-GAG complex formations. We performed time resolved CEST and T₁ relaxation time measurements and quantified the CEST effects using different CEST metrics, including MTR_asym and AREX. Our results demonstrate the necessity of T₁ correction in CEST MRI in such a case where T₁ conditions are affected, too.

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