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Abstract #5011

Accelerating CEST MRI by Exploiting Sparsity in the Z-Spectrum Domain

Grzegorz Kwiatkowski1 and Sebastian Kozerke1

1Institute for Biomedical Engineering, ETH & University of Zurich, Zurich, Switzerland

Chemical Exchange Saturation Transfer (CEST) is an emerging modality offering an enhanced sensitivity for the detection of dilute metabolites with exchangeable protons. To provide quantitative analysis, an acquisition of multiple images per Z-spectrum is required, leading to long acquisition times in practice. In this report we present a novel approach for rapid acquisition of CEST MRI that exploits sparsity in the Z-spectrum domain. Based on ex-vivo and in-vivo data, an acceleration factor of up to R=5 is shown, without significant loss in data accuracy.

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